Start of the ABC Study on Heart Disease

Albumin excretion rate (marker of endothelial dysfunction) found to increase during acute myocardial infarction and to predict early mortality (in-hospital).

C-reactive protein (inflammation) in acute myocardial infarction found to be association with heart failure and mortality.

Albumin excretion in acute myocardial infarction found associated to long-term mortality (seven years)

Atrial fibrillation during acute myocardial infarction found associated to sudden death after 7-year of follow-up.

Low-dose digitalis during acute myocardial infarction found to be protective for long-term sudden death (seven years).

ABC-1 Study on Heart Disease. The four factors of the ABC model (estimated glomerular filtration rate, albumin/creatinine excretion ratio, history of angina, and previous myocardial infarction) improved the predictive power of other traditional models for long-term event-free survival.

ABC-2 Study on Heart Disease. It identified clinical predictors of long-term mortality (twelve years) after ACS that might help prognostication, patient education, and risk modification. It showed that the analysis of the modes of death might improve the risk assessment.

ABC-3 Study on Heart Disease. It indicates that women and men with acute coronary syndrome have different long-term cardiovascular mortality risk across increasing degrees of heart failure. Gender is an independent effect modifier of heart failure for cardiovascular mortality.

ABC-4 Study on Heart Disease. The long-term prospective study showed that patients with acute coronary syndrome have a higher incidence of malignancy than the general population.

ABC-4 Study on Heart Disease. Neoplasia onset and mortality are independently associated with low baseline plasma Total Cholesterol and LDL-C levels at admission for acute coronary syndrome.

ABC-5 Study on Heart Disease. Plasma lipid levels during ACS: Association with 20-year mortality: The ABC-5* Study on Heart Disease. This prospective three-centre study of an unselected real-world patient sample showed that baseline plasma TC, LDL, HDL and triglyceride levels at the time of ACS were not associated with long-term global mortality. We observed only an independent inverse association between TC and LDL levels and non-CD death. The results are consistent for lipid measurements at admission or after one week of hospitalisation. Furthermore, the associations we found seem to be mostly independent of anti-lipid treatment, suggesting that the core prognostic issue lies on the lipid levels per se.