A place to move your ideas

Un posto dove muovere le tue idee

G. Berton, F. Cavuto, H. Mahmoud, M. Mahmoud, R. Cordiano, R. Palmieri, F. Bagato, A. Cati

CONEGLIANO GENERAL HOSPITAL, CONEGLIANO; BASSANO DEL GRAPPA GENERAL HOSPITAL, BASSANO DEL GRAPPA; THE ABC HEART DISEASE FOUNDATION, CONEGLIANO, ITALY, CONEGLIANO; MINIA UNIVERSITY HOSPITAL, MINIA; ADRIA GENERAL HOSPITAL, ADRIA; ADRIA GENERAL HOSPITAL, ADRIA; FELTRE GENERAL HOSPITAL, FELTRE; CONEGLIANO GENERAL HOSPITAL, CONEGLIANO

Purpose: To assess the combined effect of heart failure and albuminuria on the long-term mortality risk after acute coronary syndrome (ACS) through 20 years of follow-up.

Methods: This study includes 589 patients with ACS enrolled in three centres and discharged alive. Baseline clinical and laboratory data were gathered within the first 7 days of hospitalization. Survival analysis was done to investigate the long term prognostic value of HF and albuminuria after ACS.

Results: During 20 years of follow-up, 437 (74.1%) patients died; they were sig- nificantly different for many clinical features from living patients. HF at presen- tation and albuminuria were more prevalent among dead patients (41% vs. 12% p<0.0001) and (26 % vs. 7% p< 0.0001) respectively. 3rd day albumin-creatinine ratio (ACR) values were also significantly higher among them (p<0.0001). Only 3 patients did not complete the follow-up and their time was censored before 20 years. Survival analysis showed that presence of either HF or albuminuria at ad- mission with ACS is independently associated with long term mortality. Moreover, patients who suffered from both pathologies were at higher mortality risk than patients with either.

Conclusions: The Presence of heart failure and albuminuria during ACS is inde- pendently associated with long-term mortality with an additive effect.

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Welcome

In 1992, a small group of medical researchers and other participants embarked on an project to investigate new clinical factors for heart disease, studying patients with acute coronary syndrome and following them for many years. Today, the observations on the long-term survival after acute coronary syndrome are internationally acknowledged. Main results appears on the most important cardiovascular texts across the world. The study is called “the ABC heart disease study”.

Nel 1992, un piccolo gruppo di medici ricercatori ed altri operatori sanitari, iniziarono un progetto per studiare nuovi fattori clinici della malattia cardiaca, studiando pazienti con sindrome coronarica acuta e seguendoli per molti anni. Oggi, ciò che è stato osservato sulla sopravvivenza a lungo temine dopo sindrome coronarica acuta è riconosciuto a livello internazionale. I principali risultati appaiono sui maggiori testi di medicina cardiovascolare in tutto il mondo. Questo progetto è stato chiamato “the ABC heart disease study”.

Mission

The Mission of the ABC Study on Heart Disease Project is to promote the knowledge on heart disease chiefly based on the long-term follow up of the patients. And to promote citizen health supporting preventive, social, and sport activities.